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Scientific Publications

• Oncolytic virotherapy in veterinary medicine: current status and future prospects for canine patients. 2012.
  Journal of Translational Medicine. 10:3
  Sandeep S. Patil, Ivaylo Gentsche v, Ingo Nolte, Gregory Ogilvie, and Aladar A. Szalay
  Full Text.
• Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68. 2011.
  BMC Cancer. Oct 19;11:451.
  Ascierto ML, Worschech A, Yu Z, Adams S, Reinboth J, Chen NG, Pos Z, Roychoudhuri R, Di Pasquale G, Bedognetti D, Uccellini L, Rossano F, Ascierto PA, Stroncek DF, Restifo NP, Wang E, Szalay AA, Marincola FM.
  Full Text.
• Novel therapy for anaplastic thyroid carcinoma cells utilizing an oncolytic vaccinia virus carrying the human sodium iodide symporter. 2011.
  Surgery. 150: 1040-7
  Sepideh Gholami, Dana Haddad, Chun-Hao Chen, Nanhai G. Chen, Qian Zhang, Pat B. Zanzonico, and Aladar A. Szalay, Yuman Fong
  Abstract
• Bacterial glucuronidase as general marker for oncolytic virotherapy or other biological therapies. 2011.
  Journal of Translational Medicine. 9:172.
  Michael Hess, Jochen Stritzker, Barbara Härtl, Julia B. Sturm, Ivaylo Gentschev and Aladar A. Szalay
  Full Text.
• Magnetic Resonance Imaging of tumors colonized with bacterial ferritin-expressing Escherichia coli. 2011.
  PLoS ONE. Vol. 6:10.
  Philip Hill, Jochen Stritzker, Miriam Scadeng, Ulrike Geissinger, Daniel Haddad, Thomas Basse-Lusebrink, Uwe Gbureck, Peter Jakob, Aladar Szalay.
  Full Text.
• Replication efficiency of oncolytic vaccinia virus in cell cultures prognosticates the virulence and antitumor efficacy in mice. 2011.
  Journal of Translational Medicine. 9:164.
  Nanhai G. Chen, Yong A. Yu, Qian Zhang and Aladar A. Szalay
  Full Text.
• Efficient colonization and therapy of human hepatocellular carcinoma (HCC) using the oncolytic vaccinia virus strain GLV-1h68. 2011.
  PLoS ONE. Vol. 6:7, e22069.
  Ivaylo Gentschev, Meike Müller, Marion Adelfinger, Stephanie Weibel, Friedrich Grummt, Martina Zimmermann, Michael Bitzer, Qian Zhang, Yong A. Yu, Nanhai G. Chen, Jochen Stritzker, Ulrich M. Lauer, Aladar A. Szalay
  Full Text.
• Cancer therapy and diagnostics (theranostics) following treatment with recombinant oncolytic vaccinia virus strains. 2011.
  Research Advances in Biotechnology & Bioengineering. Ed. E. Mohan, 1:pp. 1-21.
  Dana Haddad, Ivaylo Gentschev, Jochen Stritzker, Aladar Szalay.
• Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virus. 2011.
  Journal of Translational Medicine. 9:36.
  Dana Haddad, Nanhai G Chen, Qian Zhang, Chun-Hao Chen, Yong A Yu, Lorena Gonzalez, Susanne G Carpenter, Joshua Carson, Joyce Au, Arjun Mittra, Mithat Gonen, Pat B Zanzonico, Yuman Fong and Aladar A Szalay
  Full Text.
• Vaccinia Virus GLV-1h237 carrying a Walker A motif mutation of mouse Cdc6 protein enhances human breast tumor therapy in mouse xenografts. 2011.
  International Journal of Oncology. 38(3):871-8.
  Hofmann E, Grummt F, Szalay A.A.
  Abstract.
• Viral-mediated oncolysis is the most critical factor in the late-phase of the tumor regression process upon vaccinia virus infection. 2011.
  BMC Cancer. 11:68
  Stephanie Weibel, Viktoria Raab, Yong Yu, Andrea Worschech, Ena Wang, Francesco Marincola, and Aladar Szalay
  Full Text.
• Oncolytic Virotherapy of Cancer. 2011.
  Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures, Cancer Growth and Progression. 295-316.
  Chen N.G., Szalay A.A.
  Abstract.
• Oncolytic vaccinia virus: a theranostic agent for cancer. 2010.
  Future Virology. November 2010, Vol. 5, No. 6, Pages 763-784.
  Chen N.G., Szalay A. A.
  Abstract.
• Enhanced tumor therapy using vaccinia virus strain GLV-1h68 in combination with a ß-galactosidase-activatable prodrug seco-analog of duocarmycin SA. (2010)
  Cancer Gene Therapy. 2010 Sep 10. [Epub ahead of print]
  Seubert CM, Stritzker J, Hess M, Donat U, Sturm JB, Chen N, Hof JM, Krewer B, Tietze LF, Gentschev I, Szalay AA.
  Abstract.
• Enterobacterial tumor colonization in mice depends on bacterial metabolism and macrophages but is independent of chemotaxis and motility. (2010)
  Int J Med Microbiol. 2010 May 21. [Epub ahead of print]
  Stritzker J, Weibel S, Seubert C, Götz A, Tresch A, van Rooijen N, Oelschlaeger TA, Hill PJ, Gentschev I, Szalay AA.
  Abstract.
• Significant growth inhibition of canine mammary carcinoma xenografts following treatment with oncolytic vaccinia virus GLV-1h68. (2010)
  Journal of Oncology. 2010:736907, 10.
  Gentschev I, Ehrig K, Donat U, Hess M, Rudolph S, Chen N, Yu Y.A., Zhang Q, Bullerdiek J, Nolte I, Stritzker J, Szalay AA.
  Full Text.
• Regression of human prostate tumors and mestastases in nude mice following treatment with the recombinant oncolytic vaccinia virus GLV-1h68. (2010)
  Journal of Biomedicine and Biotechnology. 2010: 489759.
  Gentschev I, Donat U, Hofmann E, Weibel S, Adelfinger M, Raab V, Heisig M, Chen N, Yu YA, Stritzker J, Szalay AA.
  Full Text.
• Myristoylation negative msbB-mutants of probiotic E. coli Nissle 1917 retain tumor specific colonization properties but show less side effects in immunocompetent mice. (2010)
  Bioengineered Bugs. 1:2, 139-145:March/April 2010.
  Stritzker J, Hill P, Gentschev I, Szalay AA.
  Abstract.
• The highly attenuated oncolytic recombinant vaccinia virus GLV-1h68: Comparative genomic features and the contribution of F14.5L inactivation (2009)
  Mol Genet Genomics. 2009 Oct;282(4):417-35
  Zhang Q, Liang C, Yu YA, Chen N, Dandekar T, Szalay AA.
  Abstract
• Oncolytic vaccinia viral therapy of squamous cell carcinoma (2009)
  Molecular Cancer.
  Yu Z, Li S, Brader P, Chen N, Yu YA, Zhang Q, Szalay AA, Fong Y, Wong RJ.
  Full Text.
• Anti-VEGF single chain antibody GLAF-1 encoded by oncolytic vaccinia virus significantly enhances therapy in colonized tumor xenografts (2009)
  PNAS.
  Frentzen A, Yu YA, Chen N, Zhang Q, Weibel S, Raab V, Szalay AA.
  Abstract.
• Imaging a Genetically Engineered Oncolytic Vaccinia Virus (GLV-1h99) Using a Human Norepinephrine transporter (hNET) Report Gene (2009)
  Clinical Cancer Research. 15(11):3791-3801.
  Brader P, Kelly K, Chen N, Yu YA, Zhang Q, Zanzonico P, Burnazi EM, Ghani ER, Serganova I, Hricak H, Szalay AA, Fong Y, Blasberg R.
  Abstract.
• Systemic treatment of xenografts with vaccinia virus GLV-1h68 reveals the immunologic facet of oncolytic therapy (2009)
  BMC Genomics.
  Andrea Worschech, Nanhai Chen, Yong A Yu, Qian Zhang, Zoltan Pos, Stephanie Weibel, Viktoria Raab, Marianna Sabatino, Alessandro Monaco, Hui Liu, Vladia Monsurró, R. Mark Buller, David F Stroncek, Ena Wang, Aladar A Szalay, Francesco M Marincola.
  Full text.
• The immunologic aspects of poxvirus oncolytic therapy. (2009)
  Cancer Immunology, Immunotherapy. 58:1355-1362.
  A. Worschech, D. Haddad, DF. Stroncek, E. Wang, F. M. Marincola, A. A. Szalay.
  Abstract.
• A novel recombinant vaccinia virus expressing the human norepinephrine transporter retains oncolytic potential and facilitates deep tissue imaging. (2009)
  Molecular Medicine. 15 (5-6) 144-151.
  Nanhai Chen, Qian Zhang, Yong A. Yu, Peter Brader, Inna Serganova, Ronald Blasberg, Yuman Fong, and Aladar A. Szalay.
  Full text.
• Real-time intraoperative detection of melanoma lymph node metastases using recombinant vaccinia virus GLV-1h68 in an immunocompetent animal model. (2009)
  International Journal of Cancer. 124:911-918.
  Kelly K, Woo Y, Brader P, Li S, Chen N, Yu YA, Szalay AA, Fong Y.
  Abstract.
• Regression of human pancreatic tumor xenografts in mice after a single systemic injection of recombinant vaccinia virus GLV-1h68. (2009)
  Molecular Cancer Therapeutics. 8:141-151.
  Yu YA, Galanis C, Woo Y, Chen N, Zhang Q, Fong Y, Szalay AA.
  Abstract.
• Use of an oncolytic vaccinia virus for treatment of canine breast cancer in nude mice: preclinical development of a therapeutic agent.(2008)
  Cancer Gene Therapy. 15, 85 - 93.
  Gentschev I, Stritzker J, Hofmann E, Weibel S, Yu YA, Chen N, Zhang Q, Bullerdiek J, Nolte I, Szalay AA.
  Abstract.
• Oncolytic Vaccinia Therapy for Anaplastic Thyroid Cancer In Vivo. (2008)
  Journal of Clinical Endocrinology and Metabolism. 93(11):4403-4407.
  Lin SF, Price DL, Chen CH, Brader P, Li S, Gonzalez L, Zhang Q, Yu YA, Chen N, Szalay AA, Fong Y, Wong RJ.
  Abstract.
• A novel oncolytic agent, GLV-1h68, is effective against malignant pleural mesothelioma. (2008)
  Human Gene Therapy. 19:774-782.
  Kelly K, Woo Y, Brader P, Yu Z, Riedl C, Lin S, Chen N, Yu YA, Rusch VW, Szalay AA, Fong Y.
  Abstract.
• Colonization of experimental murine breast tumors by E. coli K-12 significantly alters the tumor microenvironment. (2008)
  Cellular Microbiology. 10(6), 1235-1248.
  Weibel S, Stritzker J, Eck M, Goebel W, Szalay AA.
  Abstract.
• Establishment and characterization of conditions required for tumor colonization by intravenously delivered bacteria. (2008)
  Biotechnology and Bioengineering. 100(3), 567-578.
  Yu YA, Zhang Q, Szalay AA.
  Abstract.
• Prodrug converting enzyme gene delivery by L. monocytogenes. (2008)
  BMC Cancer. 8:94.
  Stritzker J, Pilgrim S, Szalay AA, Goebel W.
  Full Text.
• Escherichia coli Nissle 1917 facilitates tumor detection by positron emission tomography and optical imaging. (2008)
  Clinical Cancer Research. 14(8), 2295-2302.
  Brader P, Stritzker J, Riedl CC, Zanzonico P, Cai S, Burnazi EM, Ghani ER, Hricak H, Szalay AA, Fong Y, Blasberg R.
  Abstract.
• Signatures Associated with Rejection or Recurrence in HER-2/neu-Positive Mammary Tumors.
  Cancer Research. 68(7), 2436-46.
  Worschech A, Kmieciak M, Keeler JM, Bear HD, Szalay AA, Wang E, Marincola FM, Manjili MH
  Abstract.
• Treatment of anaplastic thyroid carcinoma in vitro with a mutant vaccinia virus. (2007)
  Surgery. 14 (6): 976-983.
  Shu-Fu L, Yu Z, Riedl C, Woo Y, Zhang Q, Yu YA, Timiryasova T, Chen N, Shah JP, Szalay AA, Fong Y, Wong RJ
  Abstract.
• E. coli Nissle 1917: Vom Kriegsveteran weiterentwickelt zum aktiven Kämpfer gegen Tumoren? [E. coli Nissle 1917: From War Veteran to Genetically-Directed Tumor Fighter.] (2007)
  GenomXpress, 4.07, 12-14. Review.
  Stritzker J, Szalay AA.
  Full text [German].
• Eradication of Solid Human Breast Tumors in Nude Mice with an Intravenously Injected Light-Emitting Oncolytic Vaccinia Virus. (2007)
  Cancer Research. 67 (20), 10038-46.
  Zhang Q, Yu YA, Wang E, Chen N, Danner RL, Munson PJ, Marincola FM, Szalay AA.
  Abstract.
• Proceedings of the 14th International Symposium on Bioluminescence & Chemiluminescence: Chemistry, Biology and Applications. (2007)
  World Scientific: Singapore.
  Szalay AA, Kricka LJ, Stanley PE, Hill JP. eds.
  Book summary.
• Real-time monitoring of vaccinia virus infection in cultured cells and in living mice using light-emitting proteins. (2007)
  In: Proceedings of the 14th International Symposium on Bioluminescence & Chemiluminescence: Chemistry, Biology and Applications.
  World Scientific: Singapore, 2007: 181-184.
  Chen N, Yu YA, Zhang Q, Raab V, Szalay AA.
  Book summary.
• Four-color labeling of cell culture and tumors of live mice upon infection with: GFP-Ruc and RFP-CBG99 expressing Vaccinia virus strains. (2007)
  In: Proceedings of the 14th International Symposium on Bioluminescence & Chemiluminescence: Chemistry, Biology and Applications.
  World Scientific: Singapore, 2007: 197-200.
  Raab V, Horbaschek C, Chen N, Zhang Q, Yu YA, Seubert C, Geissinger U, Worschech A, Tietze CJ, Zellner E, Le TH, Grummt F, Stritzker J, Szalay AA.
  Book summary.
• Evaluation of an in vivo gene induction system in infected tumor-bearing mice. (2007)
  In: Proceedings of the 14th International Symposium on Bioluminescence & Chemiluminescence: Chemistry, Biology and Applications.
  World Scientific: Singapore, 2007: 205-208.
  Stritzker J, Weibel S, Hill PJ, Szalay AA.
  Book summary.
• Examinations of bacterium-mediated detection of tumors in mice models. (2007)
  In: Proceedings of the 14th International Symposium on Bioluminescence & Chemiluminescence: Chemistry, Biology and Applications.
  World Scientific: Singapore, 2007: 209-212.
  Yu YA, Szalay AA.
  Book summary.
• Tumor-specific colonization, tissue distribution, and gene induction by probiotic E. coli Nissle 1917 in live mice. (2007)
  International Journal of Medical Microbiology. 297(3):151-62.
  Stritzker J, Weibel S, Hill PJ, Ölschläger T, Goebel W, Szalay AA.
  Abstract.
• Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins. (2004)
  Nature Biotechnology. 22, 313-320.
  Yu YA, Shabahang S, Timiryasova T, Zhang Q, Beltz R, Gentschev I, Goebel W, Szalay AA.
  Abstract.
• Optical imaging: bacteria, viruses, and mammalian cells encoding light-emitting proteins reveal the locations of primary tumors and metastases in animals. (2003)
  Analytical and Bioanalytical Chemistry. 377, 964-972.
  Yu YA, Timiryasova T, Zhang Q, Beltz R, Szalay AA.
  Abstract.