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Scientific Publications
patents & publications : scientific publications
In Press
Published Articles
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Oncolytic vaccinia viral therapy of squamous cell carcinoma (2009).
Molecular Cancer.
Yu Z, Li S, Brader P, Chen N, Yu YA, Zhang Q, Szalay AA, Fong Y, Wong RJ.
Abstract.
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Anti-VEGF single chain antibody GLAF-1 encoded by oncolytic vaccinia virus significantly enhances therapy in colonized tumor xenografts (2009).
PNAS.
Frentzen A, Yu YA, Chen N, Zhang Q, Weibel S, Raab V, Szalay AA.
Abstract.
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Imaging a Genetically Engineered Oncolytic Vaccinia Virus (GLV-1h99) Using a Human Norepinephrine transporter (hNET) Report Gene (2009).
Clinical Cancer Research. 15(11):3791-3801.
Brader P, Kelly K, Chen N, Yu YA, Zhang Q, Zanzonico P, Burnazi EM, Ghani ER, Serganova I, Hricak H, Szalay AA, Fong Y, Blasberg R.
Abstract.
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Systemic treatment of xenografts with vaccinia virus GLV-1h68 reveals the immunologic facet of oncolytic therapy.
BMC Genomics.
Andrea Worschech, Nanhai Chen, Yong A Yu, Qian Zhang, Zoltan Pos, Stephanie Weibel, Viktoria Raab, Marianna
Sabatino, Alessandro Monaco, Hui Liu, Vladia Monsurró, R. Mark Buller, David F Stroncek, Ena Wang, Aladar A
zalay, Francesco M Marincola.
Full text
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The immunologic aspects of poxvirus oncolytic therapy. 2009.
Cancer Immunology, Immunotherapy. 58:1355–1362.
A. Worschech, D. Haddad, D. F. Stroncek, E. Wang, F. M. Marincola, A. A. Szalay.
Abstract.
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A novel recombinant vaccinia virus expressing the human norepinephrine transporter retains oncolytic potential and facilitates deep tissue imaging. 2009.
Molecular Medicine. 15 (5-6) 144-151.
Nanhai Chen, Qian Zhang, Yong A. Yu, Peter Brader, Inna Serganova, Ronald Blasberg, Yuman Fong, and Aladar A. Szalay.
Full text.
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Real-time intraoperative detection of melanoma lymph node metastases using recombinant vaccinia virus GLV-1h68 in an immunocompetent animal model. 2009.
International Journal of Cancer. 124:911-918.
Kelly K, Woo Y, Brader P, Li S, Chen N, Yu YA, Szalay AA, Fong Y.
Abstract.
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Regression of human pancreatic tumor xenografts in mice after a single systemic injection of recombinant vaccinia virus GLV-1h68. 2009.
Molecular Cancer Therapeutics. 8:141-151.
Yu YA, Galanis C, Woo Y, Chen N, Zhang Q, Fong Y, Szalay AA.
Abstract.
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Use of an oncolytic vaccinia virus for treatment of canine breast cancer in nude mice: preclinical development of a therapeutic agent. 2008.
Cancer Gene Therapy. 15, 85 – 93.
Gentschev I, Stritzker J, Hofmann E, Weibel S, Yu YA, Chen N, Zhang Q, Bullerdiek J, Nolte I, Szalay AA.
Abstract.
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Oncolytic Vaccinia Therapy for Anaplastic Thyroid Cancer In Vivo. 2008.
Journal of Clinical Endocrinology and Metabolism. 93(11):4403-4407.
Lin SF, Price DL, Chen CH, Brader P, Li S, Gonzalez L, Zhang Q, Yu YA, Chen N, Szalay AA, Fong Y, Wong RJ.
Abstract.
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A novel oncolytic agent, GLV-1h68, is effective against malignant pleural mesothelioma. 2008.
Human Gene Therapy. 19:774–782.
Kelly K, Woo Y, Brader P, Yu Z, Riedl C, Lin S, Chen N, Yu YA, Rusch VW, Szalay AA, Fong Y.
Abstract.
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Colonization of experimental murine breast tumors by E. coli K-12 significantly alters the tumor microenvironment. 2008.
Cellular Microbiology. 10(6), 1235-1248.
Weibel S, Stritzker J, Eck M, Goebel W, Szalay AA.
Abstract.
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Establishment and characterization of conditions required for tumor colonization by intravenously delivered bacteria. 2008.
Biotechnology and Bioengineering. 100(3), 567-578.
Yu YA, Zhang Q, Szalay AA.
Abstract.
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Prodrug converting enzyme gene delivery by L. monocytogenes. 2008.
BMC Cancer. 8:94.
Stritzker J, Pilgrim S, Szalay AA, Goebel W.
Full Text.
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Escherichia coli Nissle 1917 facilitates tumor detection by positron emission tomography and optical imaging. 2008.
Clinical Cancer Research. 14(8), 2295-2302.
Brader P, Stritzker J, Riedl CC, Zanzonico P, Cai S, Burnazi EM, Ghani ER, Hricak H, Szalay AA, Fong Y, Blasberg R.
Abstract.
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Signatures Associated with Rejection or Recurrence in HER-2/neu-Positive Mammary Tumors.
Cancer Research. 68(7), 2436-46.
Worschech A, Kmieciak M, Keeler JM, Bear HD, Szalay AA, Wang E, Marincola FM, Manjili MH
Abstract.
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Treatment of anaplastic thyroid carcinoma in vitro with a mutant vaccinia virus. 2007
Surgery. 14 (6): 976-983.
Shu-Fu L, Yu Z, Riedl C, Woo Y, Zhang Q, Yu YA, Timiryasova T, Chen N, Shah JP, Szalay AA, Fong Y, Wong RJ
Abstract.
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E. coli Nissle 1917: Vom Kriegsveteran weiterentwickelt zum aktiven Kämpfer gegen Tumoren? [E. coli Nissle 1917: From War Veteran to Genetically-Directed Tumor Fighter.] 2007.
GenomXpress, 4.07, 12-14. Review.
Stritzker J, Szalay AA.
Full text [German].
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Eradication of Solid Human Breast Tumors in Nude Mice with an Intravenously Injected Light-Emitting Oncolytic Vaccinia Virus. 2007.
Cancer Research. 67 (20), 10038-46.
Zhang Q, Yu YA, Wang E, Chen N, Danner RL, Munson PJ, Marincola FM, Szalay AA.
Abstract.
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Proceedings of the 14th International Symposium on Bioluminescence & Chemiluminescence: Chemistry, Biology and Applications. 2007.
World Scientific: Singapore.
Szalay AA, Kricka LJ, Stanley PE, Hill JP. eds.
Book summary.
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Real-time monitoring of vaccinia virus infection in cultured cells and in living mice using light-emitting proteins. 2007.
In: Proceedings of the 14th International Symposium on Bioluminescence & Chemiluminescence: Chemistry, Biology and Applications.
World Scientific: Singapore, 2007: 181-184.
Chen N, Yu YA, Zhang Q, Raab V, Szalay AA.
Book summary.
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Four-color labeling of cell culture and tumors of live mice upon infection with: GFP-Ruc and RFP-CBG99 expressing Vaccinia virus strains. 2007.
In: Proceedings of the 14th International Symposium on Bioluminescence & Chemiluminescence: Chemistry, Biology and Applications.
World Scientific: Singapore, 2007: 197-200.
Raab V, Horbaschek C, Chen N, Zhang Q, Yu YA, Seubert C, Geissinger U, Worschech A, Tietze CJ, Zellner E, Le TH, Grummt F, Stritzker J, Szalay AA.
Book summary.
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Evaluation of an in vivo gene induction system in infected tumor-bearing mice. 2007.
In: Proceedings of the 14th International Symposium on Bioluminescence & Chemiluminescence: Chemistry, Biology and Applications.
World Scientific: Singapore, 2007: 205-208.
Stritzker J, Weibel S, Hill PJ, Szalay AA.
Book summary.
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Examinations of bacterium-mediated detection of tumors in mice models. 2007.
In: Proceedings of the 14th International Symposium on Bioluminescence & Chemiluminescence: Chemistry, Biology and Applications.
World Scientific: Singapore, 2007: 209-212.
Yu YA, Szalay AA.
Book summary.
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Tumor-specific colonization, tissue distribution, and gene induction by probiotic E. coli Nissle 1917 in live mice. 2007.
International Journal of Medical Microbiology. 297(3):151-62.
Stritzker J, Weibel S, Hill PJ, Ölschläger T, Goebel W, Szalay AA.
Abstract.
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Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins. 2004.
Nature Biotechnology. 22, 313-320.
Yu YA, Shabahang S, Timiryasova T, Zhang Q, Beltz R, Gentschev I, Goebel W, Szalay AA.
Abstract.
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Optical imaging: bacteria, viruses, and mammalian cells encoding light-emitting proteins reveal the locations of primary tumors and metastases in animals. 2003.
Analytical and Bioanalytical Chemistry. 377, 964-972.
Yu YA, Timiryasova T, Zhang Q, Beltz R, Szalay AA.
Abstract.
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