V-VET1 is a genetically characterized, veterinary-grade replication-competent oncolytic vaccinia virus-based therapy derived from the LIVP vaccinia virus strain. It is systemically administered to deliver a multi-pronged attack on cancer: 1) V-VET1 selectively enters and lyses (kills) cancer cells through replication and amplification within cancer cells, causing cells to rupture and viral progeny to infect neighboring cancer cells; 2) tumor vasculature is destroyed during this process, reducing significantly the blood supply that enables tumors to grow; and 3) the oncolytic process stimulates innate and adaptive immune responses resulting in tumor rejection (similar to immune-mediated tissue-specific destruction). Future derivatives of V-VET 1 can potentially carry and over-express therapeutic, deep tissue imaging, or immuno-modulatory genes for production within the tumor.

A groundbreaking canine clinical trial exploring V-VET1 in various cancers afflicting dogs is underway in conjunction with CVS Angel Care Cancer Center in Carsbad, California.